NCT06293885

Pleurodesis Using Hypertonic Glucose

PLeurodesis Using Hypertonic Glucose Administration to Treat Post-operative Air Leaks Following Lung Resection Surgery (PLUG): Phase II Randomized Feasibility Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Air leaks from unhealed lung tissue following lung resection for benign or malignant lesions are one of the most common complications following thoracic surgery, occurring after 10% of major lung resections. The purpose of this study is to investigate the efficacy of intrapleural administration of Dextrose 50% to resolve air leaks after pulmonary resection.

Conditions

• Air Leak From Lung

Interventions

Type	Name	Description
DRUG	Dextrose 50	a solution of 50% glucose (D50) will be injected into your pleural space
OTHER	Standard of Care - No Dextrose 50	Standard of Care

Timeline

• Start date: 2024-03-30
• Primary completion: 2025-04-30
• Completion: 2025-04-30
• First posted: 2024-03-05
• Last updated: 2024-03-05

Locations

1 site across 1 country: Canada