NCT06292091

A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril

An Open-label, Fixed-sequence, 3-period Crossover Exploratory Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril in Healthy Male Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: Male
• Age: 19 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the effect of urine acid-base disequilibrium on the pharmacokinetics of captopril in healthy male volunteers.

Detailed description

* Pharmacokinetic analysis of captopril before and after urine acid-base imbalance * Safety analysis

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Captopril 12.5 Mg	12.5 mg of captopril
DRUG	Sodium bicarbonate 4 G	4 g of sodium bicarbonate
DRUG	Torsemide 20 MG	20 mg of torsemide

Timeline

• Start date: 2024-02-28
• Primary completion: 2024-03-27
• Completion: 2024-04-01
• First posted: 2024-03-04
• Last updated: 2025-05-30

Locations

1 site across 1 country: South Korea