NCT06290921

Ovulation Triggering 2 vs 3 Follicles

Ovulation Trigger With Less Than 3 Follicles in Stimulated In-vitro Fertilization (IVF) Cycles

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 405 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: 18 Years – 42 Years
• Healthy volunteers: Not accepted

Summary

Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt at least one IVF cycle. Traditionally, IVF cycles producing less than 3 to 4 mature follicles (measuring at least 14 mm) have either been cancelled or converted to intra-uterine insemination (IUI) due to the low pregnancy rates associated with these cycles. The minimal number of follicles required to proceed with egg collection is based on clinical experience, having been determined by weighing the probability of implantation and pregnancy versus the risk of not obtaining quality oocytes or reaching embryo transfer when fewer mature follicles are present. This retrospective quality control study aims to compare pregnancy rates in IVF cycles producing 3 follicles measuring 14 mm and more on trigger day, versus 2 or fewer follicles.

Conditions

• Infertility

Interventions

Type	Name	Description
OTHER	Ovulation triggering	Ovulation triggering when women only 2 dominant follicles as opposed to the clinic's standard of 3 follicles or more

Timeline

• Start date: 2024-02-22
• Primary completion: 2024-04-01
• Completion: 2024-06-11
• First posted: 2024-03-04
• Last updated: 2025-03-20

Locations

1 site across 1 country: Canada