NCT06290895

Artificial Oocyte Activation

The Effect of Artificial Oocyte Activation on Blastocysts Rate in Patients With Low Fertilization Rate

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: 18 Years – 42 Years
• Healthy volunteers: Not accepted

Summary

Studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality. The utilization of Artificial Oocyte Activation (AOA) is safe and does not increase birth defects, cognition, language and motor skills. AOA is the first line of treatment in patients with globozoospermia (round headed spermatozoa). Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists and comprises about 10-15% of patients undergoing controlled ovarian hyperstimulation. The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. The European Society of Human and REproduction (ESHRE) recommends AOA in cases with failed fertilization/ low fertilization.

Conditions

• Infertility
• Ovarian Insufficiency

Interventions

Type	Name	Description
OTHER	women having had a second IVF cycle with AOA	The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. Physiological oocyte activation requires a sperm-derived enzyme called phospholipase C zeta to cause the release of calcium in the form of oscillations from internal storages.

Timeline

• Start date: 2024-02-22
• Primary completion: 2024-03-26
• Completion: 2024-03-26
• First posted: 2024-03-04
• Last updated: 2025-03-20

Locations

1 site across 1 country: Canada