NCT06289374

Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery

The LABS Study: Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery (BIORESOURCE 2: Longitudinal)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Oesophagogastric cancer (cancer of the gullet and stomach) is the fifth most common cancer in England and Wales with 16,000 new cases diagnosed every year. Survival rates are poor with only 15% surviving beyond 5 years. There is also increasing research to understand the cancer biology and factors allowing cancers to progress. It is likely there is a relationship between the cancer-specific microbiome, cells related to inflammation, which promotes cancer progression. The BIORESOURCE 1 study has established a comprehensive resource of matched samples from patients with oesophageal and gastric cancer. This longitudinal study aims to obtain further matched biosamples in the follow-up period after cancer surgery to find biomarkers that may predict treatment response, recurrence and/or long term prognosis.

Conditions

• Oesophageal Adenocarcinoma
• Gastric Adenocarcinoma

Interventions

Type	Name	Description
OTHER	Biosample collection	Collection of saliva, urine, blood, breath and quality of life questionnaires.

Timeline

• Start date: 2025-02-01
• Primary completion: 2028-06-01
• Completion: 2029-06-01
• First posted: 2024-03-01
• Last updated: 2025-02-19

Locations

1 site across 1 country: United Kingdom