NCT06284928

Metagenomic Analysis of Gut Microbiota in Untreated and Uncontrolled Hypertensive Patients

Exploration of Microbial Patterns in Hypertension: A Cross-Sectional Analysis of Gut Microbiota in Newly Diagnosed Patients (MIPHYP-CROSS Study)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 192 (actual)
• Sponsor: Xinjiang Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This observational study aims to explore the relationship between gut microbiota composition and blood pressure regulation in patients with hypertension. A total of 192 participants will be enrolled, including newly diagnosed untreated hypertensive patients, patients with uncontrolled hypertension under medication, and healthy controls. Fecal samples will be collected for metagenomic sequencing to identify microbial taxa and functional pathways associated with blood pressure levels. The findings are expected to reveal characteristic microbial patterns linked to hypertension and provide potential microbial targets for improving antihypertensive therapy.

Conditions

• Hypertension
• Gut Microbiota

Interventions

Type	Name	Description
OTHER	Fecal Sample Collection	Non-invasive stool sample collection for gut microbiota metagenomic analysis. No drug or behavioral intervention involved.

Timeline

• Start date: 2019-12-01
• Primary completion: 2020-06-01
• Completion: 2020-12-01
• First posted: 2024-02-29
• Last updated: 2026-01-02

Locations

1 site across 1 country: China