NCT06282081

Serum Neurofilament Light in Multiple Sclerosis

Serum Neurofilament Light As a Clinical Tool in Relapsing Remitting Multiple Sclerosis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 42 (estimated)
• Sponsor: Dent Neuroscience Research Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This prospective cohort study is designed to characterize the utility of sNfL as a biomarker in clinical practice. This study also aims to understand how access to sNfL measures affects patient and clinician knowledge of their disease status and capture how this may have the potential to influence clinical decision-making. Level of disability, cognitive changes, fatigue, depression, and quality of life to detect clinical and subclinical worsening will be measured. While there is strong evidence in support of sNfL as a potential biomarker, literature regarding the application of sNfL in a real-world clinical practice setting is lacking. Understanding the utility of this test to clinicians and patients as a biomarker of MS disease activity is essential. Additionally, the optimum sampling frequency in clinical practice should be investigated to further elucidate its practicality. Given recent advances in the treatment of MS, there is increasing need for convenient and accessible measures of treatment efficacy.

Conditions

• Multiple Sclerosis
• Relapsing Remitting Multiple Sclerosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum Neurofilament Light	The purpose of this research is to investigate a biomarker, called serum neurofilament light (sNfL), which is measured in blood. This study will attempt to investigate whether or not sNfL is a useful tool for clinicians in patients diagnosed with relapsing remitting multiple sclerosis.

Timeline

• Start date: 2024-04-09
• Primary completion: 2026-03-01
• Completion: 2027-03-01
• First posted: 2024-02-28
• Last updated: 2025-02-14

Locations

1 site across 1 country: United States