NCT06279078

Long-term Effect of Steroid on Metabolic Diseases in Asthmatics

Long-term Comparative Effectiveness for Osteoporosis/Osteoporosis and Metabolic Disease in Adult Asthmatic Patients Maintaining Inhaled/Systemic Corticosteroid: a Real-world Evidence

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 19,968 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this retrospective/observational study is to compare the clinical outcomes between the high-cumulative-dose group and the low- cumulative-dose group of oral/inhaled corticosteroid in the long-term management of asthma patients. The main hypothesis are: i. High cumulative dose of corticosteroid is related to the prevalence of osteoporosis/osteoporosis in the long-term management of adult asthma. ii. High cumulative dose of corticosteroid can affect populations that have a high-risk of osteoporosis (females over 50 years of age). iii. High cumulative dose of corticosteroid is related to the prevalence of diabetes mellitus, hypertension, and hyperlipidemia in the long-term management of adult asthma. iv. High cumulative dose of corticosteroid affects bone metabolism-related diagnostic tests and laboratory values and the prescription rate of bone metabolism-related medications.

Conditions

• Asthma
• Osteoporosis, Osteopenia
• Osteoporosis Risk
• Osteoporotic Fractures

Interventions

Type	Name	Description
DRUG	Corticosteroid	oral/inhaled corticosteroid

Timeline

• Start date: 2023-12-30
• Primary completion: 2024-12-30
• Completion: 2025-06-30
• First posted: 2024-02-26
• Last updated: 2025-11-17

Locations

1 site across 1 country: South Korea