NCT06278129

Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's Disease

Evaluation of the Diagnostic and Prognostic Efficacy of Magnetic Resonance Imaging in Patients With Acute Sensorineural Hearing Loss and Ménière's Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 64 (estimated)
• Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Evaluation of the diagnostic and prognostic efficacy of nuclear magnetic resonance imaging in patients with acute sensorineural hearing loss or in patients suffering from probable or definite MD. The neuroradiological and audiological evaluation are held on in the same day in order to better clarify the radiological and clinical correlates.

Detailed description

Aims of the study: 1. Evaluate the diagnostic accuracy of MRI with the collection of more specific sequences for the inner ear (3D-FLAIR) in identifying intralabyrinthine anomalies in patients with Ménière's disease or acute/subacute sudden hearing loss and not only the retrochlear pathology/neurological causes . 2. Characterize the vascular and inflammatory MRI patterns 3. Define the prognostic role of MRI with pre- and post-contrast 3D-FLAIR sequence, eliminating confounding factors such as MRI execution time, the methodology used, the effect of previous therapy and the criteria for defining improvement. 4. Correlate 4-hour 3D-FLAIR MRI imaging data with clinical and hematological data

Conditions

• Sudden Sensorineural Hearing Loss
• Meniere Disease
• Ménière's Vertigo
• Meniere's Disease Aggravated
• Inner Ear Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Vestibular myogenic potentials	observational study

Timeline

• Start date: 2018-06-19
• Primary completion: 2021-04-23
• Completion: 2025-12-31
• First posted: 2024-02-26
• Last updated: 2024-02-26

Locations

1 site across 1 country: Italy