NCT06277479

Late Effects and HRQoL in Survivors of Allo-HSCT - a Cross Sectional Study

Late Effects and Health-Related Quality of Life in Survivors of Allogeneic Hematopoietic - a Cross-sectional Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,262 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The cross-sectional study aims to describe the burden of late effects and survivorship-specific health-related quality of life in a nationwide cohort of patients treated with allo-HSCT in Denmark. Further, identify demographic, medical or personal factors associated with better self-reported health and quality of life.

Detailed description

Objective The cross-sectional study aims to describe the burden of late effects and survivorship-specific health-related quality of life in a nationwide cohort of patients treated with allo-HSCT in Denmark. Further, identify demographic, medical or personal factors associated with better self-reported health and quality of life. Method An observational, descriptive, cross-sectional study using clinical data and self-reported questionnaires to assess the occurrence of comorbidities and self-reported late effects in survivors treated with allo-HSCT in Denmark between 1970 and 2024. Study population All survivors treated for malignant or non-malignant hematological disease with allo-HCST at the age of 18-79 years from 1970-2024 in Denmark are eligible (n=1.436). Endpoints * Self-reported survivorship specific HRQoL measured by EORTC-QOL- Survivorship 100. * Degree of health literacy measured by the Health Literacy Questionnaire (HLQ). * Occurrence or degree of Chronic Graft Versus Host Disease measured by modified Lee Chronic Graft versus host disease Symptom Scale.

Conditions

• Hematological Diseases

Timeline

• Start date: 2024-05-25
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2024-02-26
• Last updated: 2025-12-18

Locations

1 site across 1 country: Denmark