NCT06277401

Exercise in Patients With Hypermobile Joints and Knee Pain

High-load Resistance Training Compared With Usual Care for Treatment of Painful Knee Joint Hypermobility in Young Adults: A Randomised Controlled Trial (the HIPEr-Knee Study)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University of Southern Denmark · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.

Detailed description

Knee joint hypermobility is common in the adult population. Patients with knee joint hypermobility and knee pain are typically managed with low intensity resistance training and proprioceptive training to reduce knee pain and improve function, but many patients do not respond well to these treatment strategies. High-load resistance training offers additional benefits to low intensity resistance training, including marked increase in muscle cross-sectional area, neural drive, and increased tendon stiffness, all important components of acquiring active knee joint stability during movement tasks and daily life. Therefore, the primary aim of this randomised controlled trial (RCT) is to investigate if high-load resistance training is superior to usual care in reducing activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.

Conditions

• Hypermobility, Joint
• Hypermobility Syndrome
• Knee Discomfort

Interventions

Type	Name	Description
OTHER	Neuromuscular training for the knee	The exercise programme includes exercises identified in literature to target muscles around the knee.
OTHER	High-load strength training for the knee	The exercise programme includes exercises identified in literature to target muscles around the knee.

Timeline

• Start date: 2024-02-21
• Primary completion: 2025-06-01
• Completion: 2026-06-01
• First posted: 2024-02-26
• Last updated: 2024-05-08

Locations

2 sites across 1 country: Denmark