NCT06276517

Hidden Impairments During Subarachnoid Haemorrhage Recovery, Description and Evolution of a Newly Described Syndrom

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Descriptive observational study in patients with spontaneous subarachnoid hemorrhage or following aneurysmal rupture to assess the presence of a post-HSA syndrome at 3 months, 6 months and 1 year, and its impact on functional outcome using the Rivermead questionnaire

Detailed description

Every year, subarachnoid hemorrhage affects 9.1 people per 100,000 worldwide, with a peak between the ages of 50 and 60. Its frequency and relatively young age of onset make it a major source of decline in healthy life years. Progress over the past thirty years has led to a 57% reduction in mortality, but these figures do not always reflect the day-to-day reality of these patients, for whom recovery remains incomplete in almost half of cases. For example, a third of patients have not returned to work at one year, and of those who have, only half have returned to work full-time. In 2020, a Norwegian team showed that, at one year, a third of patients suffer from a "post-HSA syndrome", as yet little described, but which seems very similar to the post-concussion syndrome experienced by patients after head trauma. In their study, only 3% of patients with this syndrome returned to work at one year. A better understanding of the incidence of this syndrome, as well as its evolution and determinants, is therefore essential. With this in mind, the investigators chose to assess the presence of post-SAH syndrome at 3 months and its repercussions on return to work, using the Rivermead questionnaire. Secondly, in view of the prevalence of post-traumatic stress syndrome at 3 years (a quarter of patients), the investigators wished to study the factors determining the presence of post-HSA syndrome and an inability to return to work at 3 months, 6 months, 1 year.

Conditions

• Intracranial Hemorrhages

Interventions

Type	Name	Description
OTHER	questionnaire	self-questionnaire with 16 questions, rated from 0 to 4, giving a total of 0 to 52 points.
OTHER	SS-QoL	49-question self-administered questionnaire covering 12 domains (including work/productivity, mood, social roles, family roles, personality, etc.).
OTHER	SF-36	multidimensional, generic scale, i.e. one that assesses health status independently of causal pathology, sex, age and treatment
OTHER	CIQ-R	16-question questionnaire with answers rated from 0 to 2 to assess Social reintegration
DIAGNOSTIC_TEST	BREFF	rapid frontal efficiency battery, 6 tests from 0 to 3 on each side
DIAGNOSTIC_TEST	MoCA	MoCA is a screening test for neurocognitive impairment. It comprises 11 categories scored from 0 to 6 for a total of 0 to 30 points.
OTHER	IADL	8 questions rated from 0 to 1 to assess functional outcome
OTHER	mMRS	mMRS score from 0 to 4 to assess functional outcome
OTHER	PCL-5	To assess the prevalence of post-traumatic stress using the PCL-5 self-questionnaire. PCL-5 is a 20-item self-administered questionnaire.
OTHER	Brief-Cope	28-question self-questionnaires to study patients' coping strategies

Timeline

• Start date: 2024-03-01
• Primary completion: 2028-03-01
• Completion: 2028-03-01
• First posted: 2024-02-26
• Last updated: 2026-04-06