NCT06276205

Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism

To Compare the Effectiveness of Vitamin D & Levothyroxine Combination Therapy and Levothyroxine Alone on Serum Lipid Profile in Patients With Hypothyroidism

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: King Edward Medical University · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to study the improvement of lipid levels in hypothyroid individuals after staring treatment. The main question it aims to answer is: • whether adding Vitamin D to standard therapy has any additional benefits Participants will be given Vitamin D in replacement doses according to their pre-existing Vitamin D level in addition to levothyroxine. Researchers will compare them with another group receiving only levothyroxine to see how much lipids improve in them

Conditions

• Hypothyroidism Primary
• Lipid Disorder
• Dyslipidemias

Interventions

Type	Name	Description
DRUG	Vitamin D	if Vitamin D level suboptimal, 50,000 IU/week for 8 weeks followed by 2000 IU/d if optimal Vitamin D level, 2000 IU/d
DRUG	Levothyroxin	commenced at a dose of 1.6mcg/kg/day and will be titrated 8 weekly according to response

Timeline

• Start date: 2024-03-01
• Primary completion: 2025-01-01
• Completion: 2025-01-01
• First posted: 2024-02-23
• Last updated: 2025-03-11

Locations

1 site across 1 country: Pakistan