NCT06276179

Epidural Oxycodone for Pain Management for Lower Limb Amputation

Epidural Oxycodone for Pain Management for Lower Limb Amputation: A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effect of epidural oxycodone for pain management after lower limb amputation.

Detailed description

Phantom limb pain (PLP) is often described as tingling, throbbing, sharp, pins/needles in the limb that is no longer there. It occurs more commonly in upper extremity amputations than lower extremities and tends to be intermittent in frequency. Pain severity varies, and onset can be immediate or years afterward. The preventive strategies for the PLP pain are difficult to manage and if not addressed adequately may lead to chronic pain. The perioperative role of the anesthesiologist and the acute pain physician is important in the management of somatic and sometimes neuropathic postoperative pain. Oxycodone is a semi-synthetic narcotic analgesic and historically has been a popular drug of abuse among the narcotic abusing population. Oxycodone is used orally or intravenously.

Conditions

• Epidural
• Oxycodone
• Pain
• Lower Limb Amputation

Interventions

Type	Name	Description
DRUG	Oxycodone	Patient will receive a bolus dose of 0.15 mg/kg plus 20 ml bupivacaine 0.25% followed by an infusion 0.03 mg/kg/h oxycodone plus 0.1 mL/Kg/h bupivacaine 0.125%.
DRUG	Bupivacaine	Patient will receive a bolus 20 ml bupivacaine 0.25% followed by an infusion 0.1 mL/Kg/h bupivacaine 0.125%.

Timeline

• Start date: 2024-02-24
• Primary completion: 2024-08-01
• Completion: 2024-08-01
• First posted: 2024-02-23
• Last updated: 2024-02-28

Locations

1 site across 1 country: Egypt