NCT06275425

Comparison of the Coughing Frequency of Remimazolam Total Intravenous Anesthesia Versus Inhalational Anesthesia

Comparison of the Coughing Frequency of Remimazolam Total Intravenous Anesthesia Versus Inhalational Anesthesia : a Single-blinded Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study is a randomized controlled trial. Adult patients undergoing thyroidectomy under general anesthesia at Severance Hospital and Yonsei Cancer Center are included in tis study. For intervention group, patients receive anesthesia with total intravenous remimazolam, while for control group, patients receive anesthesia with inhalation anesthetic. The primary end point of the study is to determine whether coughing during endotracheal tube extubation is less when anesthesia is maintained with intravenous remimazolam compared to inhalation anesthetics. The secondary end points are cough score (graded into 4 levels), frequency of reoperation due to postoperative bleeding, These include the frequency of hypertension during the extubation process and whether additional painkillers are used in the recovery room.

Conditions

• Thyroid Neoplasm
• Cough

Interventions

Type	Name	Description
DRUG	Total intravenous anesthesia with Byfavo	General anesthesia is maintained with intravenous continuous administration of Byfavo.
DRUG	Inhalation anesthesia with Sevoflurane	General anesthesia is maintained with Sevoflurane.

Timeline

• Start date: 2023-06-25
• Primary completion: 2023-11-29
• Completion: 2023-11-29
• First posted: 2024-02-23
• Last updated: 2024-02-23

Locations

1 site across 1 country: South Korea