NCT06271486

Pregabalin in Treatment of Postdural Puncture Headache

Pregabalin as Alternative to Epidural Blood Patch in Treatment of Postdural Puncture Headache: A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke. It involves the retrieval and analysis of cerebrospinal fluid (CSF) from the spinal cord, serving as the benchmark for diagnosing conditions like subarachnoid hemorrhage, meningitis, and specific neurological conditions. Pregabalin, an anticonvulsant medicine that blocks calcium entry, is used to treat a variety of diseases. It has been used to relieve pain in a variety of patient groups, including those with chronic pain, epilepsy, and anxiety disorders

Conditions

• Postdural Puncture Headache

Interventions

Type	Name	Description
DRUG	Pregabalin 75mg	Group A (pregabalin group) received oral pregabalin treatment administered at 150 mg daily, with 75 mg given every 12 hours.
BIOLOGICAL	An epidural blood patch (EBP)	Group B (EBP group) received active therapy in the form of an EBP
COMBINATION_PRODUCT	conservative treatment.	Group C (control group) received conservative treatment providing recommendations to the patients, including 24 hours of bed rest, stool softener, and consuming a minimum of 2.0 liters of fluid daily. Analgesics were permitted for pain relief depending on the patient's disease status.

Timeline

• Start date: 2024-02-28
• Primary completion: 2024-08-15
• Completion: 2024-08-15
• First posted: 2024-02-21
• Last updated: 2025-06-18

Locations

1 site across 1 country: Egypt