NCT06268834

Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome

Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome: A Cross-Sectional Case-Control Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.

Detailed description

The study included a total of 75 participants, with 45 individuals classified as long-term PPI users and 30 as non-PPI users. The PPI user group was defined as those who had been consistently using PPIs (specifically omeprazole, lansoprazole, pantoprazole, esomeprazole, or rabeprazole) on a daily basis for a minimum of 6 months or at least twice a week for a minimum of 2 years. The control group comprised individuals who had never used PPIs. Venous blood samples were taken from all participants to measure serum zonulin levels.

Conditions

• Proton Pump Inhibitor Adverse Reaction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood for zonulin level was drawn from the group.	Serum zonulin levels were determined by taking 5 cc blood from the antebrachial veins of the patients.

Timeline

• Start date: 2023-10-04
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2024-02-20
• Last updated: 2024-02-20

Locations

1 site across 1 country: Turkey (Türkiye)