NCT06260982

Cognitive Disorders in Hereditary Spastic Paraplegia Type 4

Cognitive Disorders and Metabolism in 18-FDG- PET in Hereditary Spastic Paraplegia Type 4 (SPG4)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Hereditary spastic paraplegia type 4 is the most frequent mutation of hereditary spastic paraplegias. It is commonly described as pure, with progressive weakness of the lower limbs, pyramidal syndrome and vesico-sphincter disorders. However, cognitive disorders have been reported for over 20 years, but remain poorly characterized.

Detailed description

Our primary objective is to describe a pattern of cognitive impairment in Hereditary Spastic Paraplegia type 4 using 18-FDG-PET metabolic imaging. As secondary objectives, we wish to study the presence of correlations between neuropsychological tests, clinical examination, 18-FDG-PET data and general and genetic data of the pathology. We also wish to investigate correlations between genotype and phenotype.

Conditions

• Spastic Paraplegia

Interventions

Type	Name	Description
RADIATION	18-FDG-PET	18-FDG-PET and neuropsychological tests (language, memory, visuo-spatial tests, etc.).

Timeline

• Start date: 2022-01-01
• Primary completion: 2025-01-01
• Completion: 2025-01-02
• First posted: 2024-02-15
• Last updated: 2024-02-15

Locations

1 site across 1 country: France