NCT06260280

Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume

Relationship Between Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume Assessed by Nuclear Magnetic Resonance in First-Year Medical Residents

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 37 (estimated)
• Sponsor: Instituto Mexicano del Seguro Social · Other Government
• Sex: All
• Age: 24 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects. Sleep disruption or deprivation leads to a loss of psychomotor skills and an increased association with various diseases. Therefore, it is critical to assess how chronic sleep deprivation affects medical residents who work long shifts, including those assigned during their training.

Detailed description

Objective: To determine if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume, assessed by nuclear magnetic resonance, in first-year medical residents assigned to the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajío, during a period of 2 months after their admission. Materials and Methods: This is a retrospective cohort study of first-year residents at UMAE T1, with a calculated sample size of 37 patients. Results are presented using descriptive statistics with mean and standard deviation or median with confidence intervals, depending on the type of variable. The relationship between MRI values and sleep deprivation will be assessed using Pearson's correlation coefficient or its non-parametric equivalent. Ethical considerations: The study will be conducted with the informed consent of the patients in accordance with the General Health Law on Research and the Helsinki Declaration of 1975. The risk associated with this study is more than minimal. Resources: Magnetic resonance studies will be performed at the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajio, under the supervision of affiliated physicians specializing in the field of radiology and a fourth year resident in Diagnostic and Therapeutic Imaging.

Conditions

• Sleep Deprivation
• Hippocampal Atrophy
• Cortical Irregularity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cerebral Nuclear Magnetic Resonance	Cerebral Nuclear Magnetic Resonance before the start of the shifts and a control 2 months after the start of the residency to evaluate if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume.

Timeline

• Start date: 2024-02-26
• Primary completion: 2024-05-26
• Completion: 2024-06-01
• First posted: 2024-02-15
• Last updated: 2024-02-15

Locations

1 site across 1 country: Mexico