NCT06259500

Patient-derived Stem Cell Models of Anorexia Nervosa

Generation and Analysis of Patient-derived Stem Cell Models of Hypothalamic Neurons and Microglia in Anorexia Nervosa

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: —

Summary

Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been possible to explore these cells at a molecular level in anorexia nervosa (AN) patients. This attributed to the obvious lack of valid tissue and non-invasive imaging techniques of high enough resolution. Stem cell models have evolved as a useful tool for the exploration of other neuropsychiatric disorders with a comparably high genetic contribution as AN. The investigators will here use patient-derived induced pluripotent stem cells (iPSCs) to profile Arc neurons and peripheral blood mononuclear cell (PBMC) derived microglia in AN, thus defining molecules to explore as drug targets.

Conditions

• Anorexia Nervosa

Interventions

Type	Name	Description
OTHER	observational	Profiling the function of iPSC derived Arcuate neurons and PBMC derived microglia

Timeline

• Start date: 2022-08-25
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2024-02-14
• Last updated: 2025-07-01

Locations

1 site across 1 country: Sweden