NCT06259097

Different Medications to Induce Labor

Misoprostol Versus Pitocin for Induction of Labor in Patients With BMI > 30: A Randomized Controlled Trial

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Icahn School of Medicine at Mount Sinai · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized controlled trial examining whether the use of misoprostol or pitocin, in combination with a foley catheter, is more effective at inducing labor in patients with a gravid BMI that is considered obese.

Detailed description

This randomized controlled trial will include patients with a BMI greater than 30 at the time of admission for their induction of labor. Patients will be randomized to either misoprostol or Pitocin to begin induction of labor, alongside the standard foley catheter, and the primary outcome of interest will be length of time from start of induction until delivery.

Conditions

• Pregnancy
• Labor

Interventions

Type	Name	Description
DRUG	Misoprostol	25 mcg vaginally every 6 hours
DRUG	Pitocin	3-6 mL intravenously every hour

Timeline

• Start date: 2024-07-02
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2024-02-14
• Last updated: 2026-03-31

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study