NCT06257485

Bronx Transthyretin Amyloid Cardiomyopathy Database

Database of Transthyretin Amyloid Cardiomyopathy Cases in a Racially and Ethnically Diverse Population in the Bronx

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 476 (estimated)
• Sponsor: Montefiore Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a commonly undiagnosed and potentially fatal disease. Contemporary studies on this condition often underrepresent the female gender and diverse patient populations. This registry retrospectively evaluated patients referred for 99mTc-pyrophosphate (PYP) Single Photon Emission Computed Tomography (SPECT) between 2014 and 2023 at Montefiore-Einstein in the Bronx. The patient population is racially and ethnically diverse and with a high proportion of females. Demographic, clinical (e.g. comorbidities), laboratory, echocardiographic, hospitalization, and mortality data were collected for each patient.

Conditions

• Transthyretin Cardiac Amyloidosis
• Transthyretin Amyloid Cardiomyopathy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	99mTc-pyrophosphate Single Photon Emission Computed Tomography	All patients underwent 99mTc-pyrophosphate Single Photon Emission Computed Tomography and had a baseline echocardiogram

Timeline

• Start date: 2023-09-23
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2024-02-14
• Last updated: 2026-01-09

Locations

1 site across 1 country: United States