NCT06253247

Effect of NanoChitosan Impregnated Calcium Hydroxide as an Intracanal Medication on Postoperative Pain Intensity and Bacterial Load Reduction

Effect of NanoChitosan Impregnated Calcium Hydroxide Paste as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Teeth: A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This research will study the effect of NanoChitosan impregnated Calcium Hydroxide versus Calcium Hydroxide as an intracanal medication on postoperative pain intensity measured using numerical rating scale (NRS) and bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml) in necrotic teeth.

Detailed description

Primary outcome: Postoperative pain measured using numerical rating scale (NRS) 1. After placement of intracanal medicament at 6, 12, 24 and 48 hours. 2. After root canal obturation at 6, 12, 24 and 48 hours. Secondary outcome: Bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml) 1. Sample 1 (S1): after access preparation and pre-instrumentation. 2. Sample 2 (S2): post-instrumentation. 3. Sample 3 (S3): post-intracanal medicament removal at 7 days.

Conditions

• Intervention

Interventions

Type	Name	Description
COMBINATION_PRODUCT	NanoChitosan impregnated Calcium Hydroxide	NanoChitosan impregnated Calcium Hydroxide used as an intracanal medication fro 7 days

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-06-01
• Completion: 2024-06-01
• First posted: 2024-02-12
• Last updated: 2024-02-12