NCT06247462

Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of New Mexico · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to determine if ibuprofen prior to exercise in the heat worsens biomarkers of acute kidney injury. Participants were given 600mg of ibuprofen or placebo (corn starch) 12- and 1-hour prior to running for 1-hour in a hot environment (35°C) at moderate intensity. Urine, plasma, and serum samples were collected pre-, post-, and 1hour post-exercise to assess biomarkers of acute kidney injury. This was a double blind, randomized crossover design, so that participants completed the alternate trial (ibuprofen or placebo) at least seven days later.

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	Ibuprofen 600 mg	600 mg of ibuprofen was ingested 12- and 1-hours prior to exercise.
DRUG	Placebo Corn Starch	600 mg of corn starch (placebo) was ingested 12- and 1-hours prior to exercise.

Timeline

• Start date: 2023-06-01
• Primary completion: 2023-09-05
• Completion: 2023-09-05
• First posted: 2024-02-08
• Last updated: 2026-01-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study