NCT06247059

Reducing Respiratory Virus Transmission in Bangladeshi Classrooms

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20,000 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 9 Years – 12 Years
• Healthy volunteers: Accepted

Summary

This study will test if affordable air cleaning devices (box fans with a filter attached and/or ultraviolet light lamps) installed in classrooms can reduce the number of viral respiratory illnesses schoolchildren experience.

Detailed description

This cluster-randomized controlled trial in Bangladesh schools will examine whether low-cost air filtration and/or human-safe ultraviolet germicidal light interventions can reduce the incidence of schoolchildren's respiratory viral infections. The main study objectives are: 1. Pilot and optimize an intervention to filter classroom air. 2. Pilot and optimize an intervention to treat classroom air with ultraviolet light. 3. Assess the separate and combined effect of air filtration and ultraviolet light on the incidence of polymerase chain reaction (PCR) confirmed illness from respiratory viruses. Methods: The study will take place in 60 government primary schools in Dhaka, Bangladesh. Within each enrolled school, 5 classrooms of students in grades 3, 4 and 5 will be randomly assigned to receive: 1. Box fans with a filter attachment. 2. 220 nanometer (nm) wavelength ultraviolet light air cleaner lamps. 3. Both the box fans with a filter and the 220 nm ultraviolet lamps. 4. No device: a control group that receives no additional device ("standard of care"). Two classrooms within each school will be assigned as controls. Why does this matter?: Clarifying the impact of low-cost practical solutions could support the adoption of these strategies that could reduce influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in schools in order to reduce the burden of respiratory illness in these communities.

Conditions

• SARS-CoV2 Infection
• Influenza Viral Infections
• Respiratory Viral Infection

Interventions

Type	Name	Description
DEVICE	Box Fan	Classrooms assigned to this arm will be equipped with 2 - 8 box fans each with a single minimum efficiency reporting value-14 (MERV-14) filter sufficient to increase effective air changes per hour to 12 based on the clean air delivery rate measured in cubic feet per minute of the box fan + filter \* 60 divided by the room volume.
DEVICE	UV Germicidal Irradiation Lamp Unit	Classrooms assigned to this arm will be equipped with one or two 222nm wavelength light ultraviolet germicidal irradiation lamp units (number of units per classroom based on room volume).
DEVICE	Combined: Box Fan and UV Germicidal Irradiation Lamp Units	Classrooms assigned to this arm will be equipped with both box fans and UV germicidal irradiation lamp units.

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-09-01
• Completion: 2027-01-01
• First posted: 2024-02-07
• Last updated: 2025-04-02