NCT06243133

Pair Antiplatelet THerapy in Ischemic Stroke With Intracranial Artery Stenosis

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,100 (estimated)
• Sponsor: Sichuan Provincial People's Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn about efficacy and safety of dual antiplatelet therapy in ischemic stroke with intracranial artery stenosis. The main question it aims to answer are: whether aspirin combined with clopidogrel for 3 month is better than 1 months for patients with non-cardiogenic cerebral infarction with intracranial artery stenosis. Participants will get dual antiplatelet therapy (aspirin plus clopidogrel) for 1 month or 3 months within 7 days of the first stroke. Researchers will compare experimental group (3 months dual antiplatelet therapy) with comparison group (1 month dual antiplatelet therapy), to see if experimental group would reduce stroke recurrence or mortality, and increase bleeding and other adverse prognosis.

Conditions

• Ischemic Stroke
• Intracranial Arteriosclerosis
• Secondary Prevention
• Antiplatelet Drug

Interventions

Type	Name	Description
DRUG	clopidogrel for 90 days combined with aspirin for 90 days	Clopidogrel 300mg on the first day, then 75mg/day for 90 consecutive days; Aspirin 100mg/day for 90 days
DRUG	clopidogrel for 30 days combined with aspirin for 90 days	Clopidogrel 300mg on the first day, then 75mg/ day for 30 consecutive days; Aspirin 100mg/ day for 90 days

Timeline

• Start date: 2024-07-01
• Primary completion: 2026-03-31
• Completion: 2026-03-31
• First posted: 2024-02-06
• Last updated: 2024-06-18

Locations

1 site across 1 country: China