NCT06242678

Evaluating Spinal Cord Stimulation for Stiff Person Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this prospective pilot study is to gather preliminary evidence evaluating spinal cord stimulation (SCS) as a potential therapy for the treatment of rigidity and painful spasms in patients with stiff person syndrome (SPS), a rare autoimmune neurological condition. The hypothesis is that SCS-mediated clinical improvement occurs through multi-modal mechanisms of action targeting several components of neuronal inhibitory signaling pathways in the spinal cord.

Detailed description

The hypothesis is that SCS-mediated clinical improvement occurs through multi-modal mechanisms of action targeting several components of neuronal inhibitory signaling pathways in the spinal cord.

Conditions

• Stiff-Person Syndrome

Interventions

Type	Name	Description
DEVICE	SCS trial lead	placement of spinal cord stimulator trial leads to see if effective in the management of symptoms associated with stiff person syndrome

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-08-21
• Completion: 2025-10-27
• First posted: 2024-02-05
• Last updated: 2026-01-29

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study