NCT06240312

Optic Nerve Head Strain as Biomarker for Glaucoma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 130 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.

Detailed description

Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.

Conditions

• Glaucoma, Open-Angle

Interventions

Type	Name	Description
DEVICE	Images of eye at 2 eye pressures	subject images of the eye's optic nerve head are studied

Timeline

• Start date: 2024-07-01
• Primary completion: 2028-01-31
• Completion: 2028-01-31
• First posted: 2024-02-05
• Last updated: 2025-06-15

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study