NCT06237907

Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema

The Role of Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Detailed description

This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Conditions

• Lymphedema

Interventions

Type	Name	Description
OTHER	Patients underwent lymphedema surgery	Patients who have developed lymphedema and undergone lymphedema surgery.
OTHER	Patients underwent surgery without LVA	For patients who have not experienced lymphedema but require surgery due to other disease such as cancer, trauma, chronic wounds, skin defects, etc.

Timeline

• Start date: 2023-09-20
• Primary completion: 2024-09-20
• Completion: 2026-01-12
• First posted: 2024-02-02
• Last updated: 2024-02-02

Locations

1 site across 1 country: Taiwan