Trials / Recruiting
RecruitingNCT06236048
Energetics and Glutamate in Schizophrenia
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 75 (estimated)
- Sponsor
- King's College London · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
The goal of this case-control study is to compare brain glutamate, glucose utilisation, lactate production and brain activity in healthy volunteers and people with a diagnosis of schizophrenia. It investigates the following main questions: Whether, compared to healthy volunteers, participants with schizophrenia show: 1. reduction in brain glucose utilisation 2. increased brain lactate 3. greater variability in brain glutamate Participants will be asked to have a screening visit, a MRI brain scan and a PET-MRI brain scan.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | MRI scan | 7 Tesla MRI scan |
| PROCEDURE | PET-MR scan | 18F-fluorodeoxyglucose PET-MR scan |
Timeline
- Start date
- 2024-03-04
- Primary completion
- 2027-12-31
- Completion
- 2028-12-01
- First posted
- 2024-02-01
- Last updated
- 2025-09-05
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT06236048. Inclusion in this directory is not an endorsement.