NCT06235476

Protein Intake and Exercise-induced Muscle Damage

Comparing the Effects of Three PROtein-enhancement Strategies on Exercise-induced Muscle Damage in Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 199 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to test the effect of different protein-enhancement strategies versus carbohydrate control on exercise-induced muscle damage in physically active older adults. The main question it aims to answer is: What is the effect of three different protein-enhancement strategies (whey protein (WP), mixed plant-based protein (MPP), and use of protein-rich food products (PFP) on exercise-induced muscle damage in older adults compared to isocaloric carbohydrate control? Participants will: * Use a protein-enhancement strategy (WP, MPP or PFP) or carbohydrate control for a total of 5 weeks; * Participate in a single walking bound (30/40/50 km) two weeks after the start of the study; * Participate in a consecutive walking bound (4 days of 30/40/50 km) in the last week of the study period; * Complete different questionnaires and give blood samples to test for muscle damage.

Conditions

• Sarcopenia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	whey protein supplement	Daily dosage of the supplements will be 30 gram, preferably consumed in the morning and post-exercise or prior to sleep.
DIETARY_SUPPLEMENT	mixed plant-based protein supplement	Daily dosage of the supplements will be 30 gram, preferably consumed in the morning and post-exercise or prior to sleep.
OTHER	e-health application	Daily use of an e-health application with dietary intake counselling to increase protein intake. The overall goal of these advices is to increase protein intake from \<1.0g/kg/bw/d to \>1.2g/kg/bw/d which is approximately 30 grams of additional protein per day (similar to the other arms of the intervention).
DIETARY_SUPPLEMENT	isocaloric carbohydrate control	Daily dosage of the supplements will be 30 gram, preferably consumed in the morning and post-exercise or prior to sleep.

Timeline

• Start date: 2024-06-10
• Primary completion: 2024-07-19
• Completion: 2025-07-31
• First posted: 2024-02-01
• Last updated: 2025-11-17

Locations

1 site across 1 country: Netherlands