Trials / Not Yet Recruiting
Not Yet RecruitingNCT06235320
Paracetamol Effect on Prostaglandins and Blood Pressure
Paracetamol Impact Study: Prostaglandin Synthesis and Blood Pressure Effects (PIS-PaB)
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 72 (estimated)
- Sponsor
- Charite University, Berlin, Germany · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | routine clinical treatment of pain with paracetamol or ibuprofen | No intervention beside clinical routine management |
Timeline
- Start date
- 2025-03-01
- Primary completion
- 2026-03-01
- Completion
- 2026-09-01
- First posted
- 2024-01-31
- Last updated
- 2025-02-26
Source: ClinicalTrials.gov record NCT06235320. Inclusion in this directory is not an endorsement.