NCT06232486

Relationship Between Serum Vitamin D Levels and Postherpetic Neuralgia.

Association Between Serum Vitamin D and Postherpetic Neuralgia, A Prospective Observation Study.

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 144 (estimated)
• Sponsor: Feng Gao · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

1. The correlations of serum vitamin D level, serum calcium level and osteoporosis degree with disease severity, treatment response, incidence of Post-Herpes zoster(PHN) and disease prognosis in Herpes zoster(HZ) patients were studied. 2. To investigate the role of inflammation-related factors and immune-related factors in the occurrence and development of HZ mediated by low vitamin D level.

Detailed description

Herpes zoster is a neuropathic disease which induce by the varicella-herpes virus reactivation.and postherpetic neuralgia (PHN) is the most common complication. Currently,the mechanism of herpes zoster still unclearly even though there had much study about it .Vitamin D is an essential vitamin for human body, which has the function of maintaining calcium and phosphorus homeostasis and immune regulation. Vitamin D is a natural antiviral substance, and vitamin D deficiency can affect the body's antiviral ability, thereby promoting varicella-zoster virus(VZV) reactivation, and may promote the development of PHN through continuous neuroinflammation. Therefore, vitamin D level may be related to the occurrence and progression of HZ. this study intends to use an observational cohort study design to investigate the correlation of serum vitamin D level and osteoporosis degree with the severity of the herpes zoster disease, Although we plan to further explore the role of inflammatory state in this process.

Conditions

• Postherpetic Neuralgia

Timeline

• Start date: 2023-12-01
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2024-01-30
• Last updated: 2024-01-30

Locations

1 site across 1 country: China