NCT06230783

Speech Pattern Evaluation and Analysis for Knowledge of AD

Connected Language and Speech Along the Spectrum of ADRD: Digital Assessment and Monitoring

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 165 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease. Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.

Detailed description

Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer's disease pathology, with the potential for highly accessible, yet low-burden measurement. In this project, researchers will recruit a subset of participants from two longitudinal, observational cohort studies enriched for individuals at risk for or living with Alzheimer's disease to record their speech at home with a mobile device, longitudinally. Our interdisciplinary team will then validate digital markers across all stages of Alzheimer's Disease and Related Dementias (ADRD), including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.

Conditions

• Wisconsin Alzheimer's Disease Research Center
• Wisconsin Registry for Alzheimer's Prevention

Interventions

Type	Name	Description
OTHER	TalkTracker	Participants will be asked to complete the speech collection procedures remotely/at home once per week for 8 weeks. The 8-week period of weekly remote speech collection will take place yearly for a total of 3 years. At the end of each 8-week study period for years 1-3, participants will complete a survey that asks questions about how easy/difficult the application was to use, how frustrated they felt using the application, and other usability questions.

Timeline

• Start date: 2025-01-22
• Primary completion: 2029-02-01
• Completion: 2029-02-01
• First posted: 2024-01-30
• Last updated: 2026-03-12

Locations

1 site across 1 country: United States