NCT06228729

Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

Detailed description

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli. Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Conditions

• Abdominal Surgery
• Endotracheal Intubation
• Surgical Incision
• Electroencephalogram

Interventions

Type	Name	Description
PROCEDURE	Endotracheal intubation	Inserting endotracheal tube into the trachea

Timeline

• Start date: 2025-04-01
• Primary completion: 2025-10-28
• Completion: 2025-11-21
• First posted: 2024-01-29
• Last updated: 2026-01-06

Locations

1 site across 1 country: South Korea