NCT06228651

The Effect of the Tourniquet in Bilateral Total Knee Replacement

The Functional Outcome of the Arterial Tourniquet in Total Knee Arthroplasty- a RCT of Bilateral Total Knee Arthroplasties.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Odense University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study describes in a randomised controlled trial how the tourniquet influence the outcome af a total knee replacements

Detailed description

Background: Tourniquet application during total knee arthroplasty (TKA) is a common practice aimed at reducing intraoperative bleeding. However, concerns have been raised about potential tissue damage from ischemia and reperfusion injury. Objectives: This study examines the effects of tourniquet use during TKA on postoperative functional outcomes, including pain, range of motion (ROM), and patient-reported outcomes (PROMs). Methods: In a fast-track surgical setting, a prospective, randomized, double-blinded trial was conducted with patients undergoing bilateral TKA. Tourniquets were applied to one knee, while the contralateral knee served as a control. Evaluations were conducted at two and four weeks, and at three and twelve months postoperatively, employing paired t-tests and mixed-effects linear modeling for data analysis.

Conditions

• Tourniquet and Outcome After Total Knee Replacement

Interventions

Type	Name	Description
DEVICE	Tourniquet
OTHER	The leg without the tourniquet

Timeline

• Start date: 2016-03-14
• Primary completion: 2021-03-01
• Completion: 2023-12-21
• First posted: 2024-01-29
• Last updated: 2024-01-29