NCT06225869

Effect of Dopamine on Specific Processing of Shame and Embarrassment in Parkinson's Disease

Impact of Dopamine Replacement Therapy on Shame and Embarrassment-specific Processing and Its Clinical Relevance in Parkinson's Disease Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Shame and embarrassment are two self-conscious emotions frequently experienced by Parkinson's disease (PD) patients. Shame and embarrassment scores strongly correlate with patient's quality of life, anxiety and depression ratings. However, the neurobiology of shame and embarrassment in PD and the influence of dopaminergic replacement therapy (DRT) is poorly understood. The aim of this study is to characterize how brain structures and neuronal networks involved in Parkinson's disease-related shame, non-Parkinson's disease related shame and neutral control scenarios, are modulated by dopaminergic replacement therapy. For this purpose, functional MRI and connectivity measures between the basal ganglia and shame-related network will be analyzed while PD patients will perform a shame-induction task during both ON- (i.e. during the effect of DRT) and OFF-DRT (i.e. during the withdrawal of DRT) conditions. Correlation with clinical measures will be made.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
BEHAVIORAL	Assessments in ON and OFF levodopa state	Neurological assessment, neuropsychological assessment, and fMRI in ON and OFF levodopa state

Timeline

• Start date: 2023-04-19
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2024-01-26
• Last updated: 2024-03-05

Locations

1 site across 1 country: Switzerland