NCT06225154

Effect of Periodontal Treatment on Adipokine Levels

Effect of Non-Surgical Periodontal Treatment on Adipokine Levels in Diabetes Mellitus: A Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Marmara University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).

Detailed description

The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.

Conditions

• Periodontitis
• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
PROCEDURE	Non-surgical periodontal treatment	Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.

Timeline

• Start date: 2015-02-01
• Primary completion: 2016-05-01
• Completion: 2016-11-01
• First posted: 2024-01-25
• Last updated: 2024-01-30

Locations

2 sites across 2 countries: Finland, Turkey (Türkiye)