NCT06217627

Skin Rejuvenation Using Stem Cell Secretome

The Potential of Umbilical Cord Stem Cell Secretions in Skin Rejuvenation

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: COR clinic of Regenerative Medicine · Network
• Sex: Female
• Age: 25 Years
• Healthy volunteers: Accepted

Summary

This clinical trial aims to investigate the effect of umbilical cord explants (UC)-explants and UC-mesenchymal stem cells (MSCs) secretome on skin rejuvenation, to provide future reference or standard in the application of cell free-based therapy in skin aging.

Detailed description

This trial is a pilot clinical trial evaluating the effect of the secretions of umbilical cord explants and mesenchymal stem cells on skin rejuvenation. Also the concentration of selected growth factors was assessed in the secretome derived from UC-explants and UC-MSCs. Healthy women participants, after their consent, received secretome injections in their hands, face, and neck. Outcomes were assessed on the Hand Volume Rating Scale, Wrinkle Severity Rating Scale, and through histologic examination of skin biopsy at two different times: before treatment and after 12 months. A digital camera was used to obtain photographs of hands, face, and Neck at each visit. These were assessed by a single-blinded dermatologist. SPSS software version 26 (64-bit) was used for all analyses. Participants provided written informed consent and were asked not to change their routine skin care habits during the study.

Conditions

• Skin Rejuvenation

Interventions

Type	Name	Description
BIOLOGICAL	secretome	The secretome is the secretions of MSCs or explants from umbilical cord tissues. It contains diverse trophic molecules including cytokines, chemokines, angiogenic factors, and growth factors.

Timeline

• Start date: 2021-03-05
• Primary completion: 2023-01-25
• Completion: 2023-06-30
• First posted: 2024-01-22
• Last updated: 2024-02-06

Locations

1 site across 1 country: Lebanon