NCT06213909

Retrospective Study of the Effects of Sub-pathologic Phenotypes of BP on Clinical Management and Prognosis

A Retrospective Study of the Effects of Different Pathologic Phenotypes of Bullous Pemphigoid on Clinical Management and Prognosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 318 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 0 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Bullous pemphigoid (BP) is a chronic autoimmune subepidermal blistering disease primarily affecting the elderly with a significant risk of mortality and morbidity. Various inflammatory cells such as eosinophils, lymphocytes, neutrophils and their granulopoiesis play an important role in the pathogenesis of BP. Infiltration of peripheral blood eosinophils, lymphocytes, and neutrophils into the skin is considered a major feature of BP, making it a heterogeneous disease with different histologic and clinical subtypes. This clinical study was conducted to further investigate the impact of different pathologic phenotypes of BP on the treatment and prognosis of the disease. A retrospective epidemiologic investigative approach was used，and case collection included demographic information, medical history, clinical manifestations, and histopathologic features. Including gender, age, duration of disease, number of days of hospitalization, mucosal involvement, clinical diagnosis before admission, histopathological diagnosis, laboratory tests, concomitant diseases, treatment and its changes in laboratory indexes before and after treatment.

Conditions

• Bullous Pemphigoid

Interventions

Type	Name	Description
OTHER	This is a retrospective analysis of health data from inpatient record, no intervention was designed	This is a retrospective analysis of health data from inpatient record, no intervention was designed

Timeline

• Start date: 2024-01-11
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2024-01-19
• Last updated: 2024-01-19

Locations

1 site across 1 country: China