NCT06212830

Pain Relief After Corneal Collagen Cross-Linking

Enhancing Pain Relief After Corneal Collagen Cross-Linking: Exploring New Post-Surgical Treatments

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 51 (estimated)
• Sponsor: Assaf-Harofeh Medical Center · Other Government
• Sex: All
• Age: 15 Years – 100 Years
• Healthy volunteers: Accepted

Summary

Keratoconus is a progressive corneal ectasia that can lead to significant visual impairment and decreased quality of life. The introduction of corneal cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has revolutionized the treatment of keratoconus by increasing corneal rigidity and arresting disease progression. The epithelium-off protocol, which induces heightened post-surgical discomfort, is the prevailing approach. Despite the success of CXL, postoperative pain is a common side effect that can negatively impact patients' quality of life and impede recovery. Pain management after CXL is essential for optimizing patient outcomes and satisfaction. Systemic painkillers, though not researched enough, may potentially aid in healing and recovery, minimizing complications and discomfort for the patient. In this study we will provide evidence-based recommendations for clinicians to optimize pain control after CXL in collaboration with pain specialists.

Conditions

• Provide Evidence-based Recommendations for Clinicians to Optimize Pain Control After CXL

Interventions

Type	Name	Description
DRUG	Gabapentin	Gabapentin 200 mg twice a day, starting from the night prior to the procedure and continue 48 hours after
DRUG	Targin	Targin 5 mg twice a day after the procedure for 48 hours
DRUG	NSAID	Nurofen (NSAID) 200 mg twice a day after the procedure for 48 hours
DRUG	Paracetamol	Paracetamol 500 mg every 4 hours during waking hours after the procedure for 48 hours

Timeline

• Start date: 2024-02-01
• Primary completion: 2025-02-01
• Completion: 2025-08-01
• First posted: 2024-01-19
• Last updated: 2024-01-19

Locations

1 site across 1 country: Israel