NCT06212765

Oral Citrulline Supplementation in COPD Patients With Malnutrition

Effects of Oral Citrulline Supplementation on Fat-free Mass in COPD Patients With Malnutrition

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

Chronic obstructive pulmonary disease (COPD) is complicated by malnutrition in 20-70% of cases. In COPD, low fat-free mass is associated with a higher risk of morbidity and mortality. L-citrulline is a non-protein amino acid that has a direct effect on muscle protein synthesis. Oral supplementation with L-citrulline (10 g/day) in malnourished patients has shown to increase fat-free mass. The effects of L-citrulline supplementation in malnourished COPD patients are unknown. The main objective of this prospective, single-centre, randomised, double-blind, placebo-controlled study will be to determine the impact of 45 days of nutritional supplementation with L-citrulline (10 g/day) on lean body mass (fat-free mass index (in kg.m-2) measured by bioelectrical impedance analysis) in malnourished patients (BMI \< 20 kg/m2 if \< 70 years old or \< 22 kg/m2 if ≥ 70 years old) with COPD at stages 3-4 of the GOLD classification.

Conditions

• Chronic Obstructive Pulmonary Disease Severe
• Malnutrition

Interventions

Type	Name	Description
DRUG	L-citrulline	to take 1 pod a day for 45 days

Timeline

• Start date: 2024-01-25
• Primary completion: 2026-01-25
• Completion: 2026-09-25
• First posted: 2024-01-19
• Last updated: 2024-01-19