NCT06211478

Role of Vitamin E in Gaucher Disease Patients

Role of Vitamin E as an Adjuvant Therapy for Patients With Gaucher Disease Under Enzyme Replacement Therapy in Relation to Oxidative Stress

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 2 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

gaucher disease (GD) can be classified into three clinical types .type 1,the most common type ,is the chronic non neuronpathic form of the disease,which shows gighly variable signs and symptoms and variable course,with visceral,skeletal and hematologic involvement among others.the neurologocal involvement can be observed in types 2 and 3

Detailed description

enzymatic defeciency in gaucher disease patients may induce a cascade of events that result in side effects, such as the production of reactive oxygen species(ROS) and reactive nitrogen species(RNS) that can then generate the oxidative stress whereas in body of healthy individuals,the production and degradation of ROS and RNS are generally balanced. neurochemical abnormalities in patients with gaucher disease might be related to oxidative stress and inflammation in the brain. oxidative stress induces peroxiredoxin-2 as cytoprotective response against RNS .it is able to detoxify a vast range of organic peroxides. vitamin E well accepted nature most effective lipid soluble chain breaking antioxidant .

Conditions

• Gaucher Disease

Interventions

Type	Name	Description
DRUG	Vitamin E	Vitamin E will be taken for 6 months for gaucher disease patients who have oxidative stress and vitamin E defecient

Timeline

• Start date: 2023-03-03
• Primary completion: 2023-09-05
• Completion: 2023-10-05
• First posted: 2024-01-18
• Last updated: 2024-01-18

Locations

1 site across 1 country: Egypt