NCT06209437

Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers

The Effect of Total Intravenous Anesthesia or Inhalation Anesthesia on Inflammatory Biomarkers in Coronary Artery Bypass Surgery and Their Relationship With Early Postoperative Complications a Prospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 228 (actual)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative complications. The main questions it aims to answer are * Does the type of anesthesia have a relationship with inflammatory biomarkers? * Are inflammatory biomarkers associated with postoperative complications?

Detailed description

This study is planned to be a prospective observational clinical study. Patients who will undergo on-pump coronary artery bypass surgery, meet the eligibility criteria and agree to participate in the study and sign the informed patient consent form will be included in the study.Systemic immune inflammatory index, systemic inflammatory response index, neurophile lymphocyte ratio, platelet lymphocyte ratio will be calculated in the routine complete blood count of patients in the last 3 preoperative days and in the first 24 hours postoperatively.It will be evaluated whether these biomarkers are related to the anesthesia technique used, patients comorbidities and the complications that develop in the first 24 hours postoperatively. Patients will be evaluated preoperatively, intraoperatively and postoperatively; preoperative comorbidities, intraoperative anesthesia management, cross clamp, pump and surgery times, blood and blood product transfusion, inotrope use and complications that develop up to the first 24 hours postoperatively will be recorded.The anesthetic technique to be used will be determined according to the anesthesiologist's preference and will be recorded.

Conditions

• Coronary Artery Disease
• Postoperative Complications
• Anesthesia

Timeline

• Start date: 2024-01-08
• Primary completion: 2024-05-01
• Completion: 2024-06-01
• First posted: 2024-01-17
• Last updated: 2024-06-04

Locations

1 site across 1 country: Turkey (Türkiye)