NCT06208904

The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The present study investigates the involvement of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) in the pathophysiology of postprandial hypotension (PPH)

Detailed description

The study is an exploratory, randomised, placebo-controlled, double-blind crossover study comprising two experimental days with an infusion of the GIP receptor antagonist, GIP(3-30)NH2 (NH2 is the aminogroup), and placebo (saline) during a 180-minute mixed meal test (MMT). Eighteen participants, men and women, with MMT confirmed PPH will be included in the study.

Conditions

• PostPrandial Hypotension

Interventions

Type	Name	Description
OTHER	Intravenous infusion of GIPRA	Intravenous infusion of GIP(3-30)NH2 in a concentration of 1,000 pmol/kg/min during experimental days
OTHER	Intravenous infusion of saline	Intravenous infusion of isotonic saline 9 mg/ml added 0,5% human serum albumin during experimental days

Timeline

• Start date: 2024-05-15
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-01-17
• Last updated: 2025-03-14

Locations

1 site across 1 country: Denmark