NCT06208202

Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling Agents (R01)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Ohio State University Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 21 Years – 29 Years
• Healthy volunteers: Accepted

Summary

This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.

Detailed description

PRIMARY OBJECTIVES: I. Assess the abuse liability of e-liquids with and without the presence of synthetic cooling agents. II. Determine the impact of synthetic cooling agents and flavor on EC puffing behavior (topography). III. Determine the exposure ranges (harmful and potentially harmful constituents \[HPHCs\], other toxicants) from vaping e-liquids with and without the presence of synthetic cooling agents. OUTLINE: Participants attend 4 sessions where they receive 1 of 4 randomly assigned flavored e-cigarettes. Participants use the e cigarettes for vaping followed by ad libitum vaping. Participants also complete surveys and undergo biosample collection throughout the study.

Conditions

• Abuse Tobacco
• Exposure

Interventions

Type	Name	Description
BEHAVIORAL	Behavioral Intervention	Receive and use flavored e-cigarettes (EC) as directed
OTHER	Biospecimen Collection	Undergo biosample sample collection
OTHER	Survey Administration	Complete surveys

Timeline

• Start date: 2024-05-08
• Primary completion: 2027-12-01
• Completion: 2028-06-01
• First posted: 2024-01-17
• Last updated: 2026-03-23

Locations

1 site across 1 country: United States