NCT06208020

Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

Cortical Activation and Functional Connectivity Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: The First Affiliated Hospital of Zhengzhou University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared spectroscopy (fNIRS). The main questions it aims to answer are: * The alteration of cortical activation during swallowing in patients with LMS compared with healthy subjects. * The alteration of cortical functional connectivity during swallowing in patients with LMS compared with healthy subjects. fNIRS will be used to detect cortical activation and functional connectivity during swallowing tasks in LMS patients and healthy subjects, and to compare the differences between patients and healthy subjects.

Conditions

• Deglutition Disorders
• Lateral Medullary Syndrome

Interventions

Type	Name	Description
OTHER	Functional near-infrared spectroscopy (fNIRS) detection	fNIRS( NirScan Danyang Huichuang Medical Equipment Co. Ltd., China) will be used to detect changes in HbO and HbR during rest and voluntary swallowing. The swallowing procedure will be used consisted of three phases of manipulations: 30-s resting state periods, 30-s swallowing periods and 30-s resting state periods. A pre-collection will be conducted before the formal collection so that the subjects could understand the test process. After the pre-collection, the subjects will take a rest for 5 minutes before the formal collection.

Timeline

• Start date: 2023-05-31
• Primary completion: 2024-01-31
• Completion: 2024-02-15
• First posted: 2024-01-17
• Last updated: 2024-01-19

Locations

1 site across 1 country: China