NCT06207786

Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery

Efficacy of Intranasal Povidone Iodine Swab Versus Oral Antibiotic Prophylaxis to Prevent Surgical Site Infections in Patients Undergoing Mohs Micrographic Surgery

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare surgical site infection rates for patients treated with Mohs micrographic surgery after bilateral nasal swab with povidone iodine versus standard treatment including the use of a standardized oral antibiotic prophylaxis protocol.

Conditions

• Skin Cancer
• Skin Cancer Face
• Malignant Cutaneous Adnexal Neoplasm

Interventions

Type	Name	Description
OTHER	Povidone-Iodine Swabs	Undergo nasal swab of both nostrils for 30 seconds into each nostril, allowing two minutes to dry, immediately (e.g. within 30 minutes) prior to performing skin reconstruction.
DIAGNOSTIC_TEST	Staphylococcus nasal swab	Undergo a nasal swab to identify patients with preoperative nasal Staphylococcus aureus colonization
DRUG	Antibiotic	Receive an oral anti-staphylococcal antibiotic (e.g. oral cephalexin) with standard dosing only if indicated for antibiotic prophylaxis per the Mayo Clinic Dermatologic Surgery Antibiotic Prophylaxis protocol that is currently standard practice for patients undergoing Mohs micrographic surgery (MMS)

Timeline

• Start date: 2024-09-01
• Primary completion: 2029-05-01
• Completion: 2030-05-01
• First posted: 2024-01-17
• Last updated: 2024-11-25