NCT06206005

Four Mandibular Implant-retained Overdentures in Individuals With Type 2 Diabetes

Clinical and Radiographic Outcomes Around Four Mandibular Implant-retained Overdentures in Individuals With Type 2 Diabetes: A Long-term Retrospective Preliminary Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 55 Years – 65 Years
• Healthy volunteers: —

Summary

Studies clinically evaluate the long-term outcome of 4 implant attachment-retained mandibular OVDs among patients with high glycemic levels are lacking.

Detailed description

Chronic hyperglycemia is considered as a typical risk-factor that causes soft tissue inflammation and bone loss around natural teeth and implants. One possible explanation for this mechanism is that chronic hyperglycemia has the propensity to increase the levels of accumulated glycation end products (AGEs) in the serum and oral tissues that accelerates the production of proinflammatory cytokines that induce bone destruction around natural teeth and implants. However, it is relevant to indicate that dental implants in chronic hyperglycemia under ideal glycemic conditions can successfully osseointegrate and show predictable outcomes over long durations in both diabetic and non-diabetic patients. Studies clinically evaluate the long-term outcome of 4 implant attachment-retained mandibular OVDs among patients with high glycemic levels are lacking.

Conditions

• Bone Resorption

Interventions

Type	Name	Description
OTHER	Observational study	evaluate implant survival, peri-implant outcome of 4 implant retained mandibular OVD after 10 years of function.

Timeline

• Start date: 2023-12-04
• Primary completion: 2024-05-05
• Completion: 2024-08-05
• First posted: 2024-01-16
• Last updated: 2024-01-26

Locations

1 site across 1 country: Egypt