NCT06203353

Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

Evaluation of the Diaphragm Tissue Doppler Parameters in Predicting Weaning From Mechanical Ventilation Outcome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Mongi Slim Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support). Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Detailed description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale \> 13 Requiring no vasopressor support conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test. Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Conditions

• Mechanical Ventilation Weaning

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	diaphragm ultrasound monitoring	Ultrasound measure the diaphragm excursion, thickening fraction and maximal contraction and relaxation velocities

Timeline

• Start date: 2023-11-01
• Primary completion: 2024-11-30
• Completion: 2024-12-30
• First posted: 2024-01-12
• Last updated: 2024-01-12

Locations

1 site across 1 country: Tunisia